desprendimiento de retina por traumatismo

In this study the antioxidant effect of Ganoderma lucidum on the cellular degeneration extracellular matrix and retinal barrier in retina after head trauma was investigated. Clinical and experimental studies have shown increased expression of MMP2 in diabetic subjects (Das et al., 1999). Matrix metalloproteinase-2 (MMP2), one of the most ubiquitous members of the matrix metalloproteinase family, cleaves collagen type IV of the extracellular matrix maintaining equilibrium between matrix synthesis and degradation, thus providing a critical role in the cell integrity and cell survival (Malemud, 2006). Damage to the optic nerve (ON) causes immediate shearing of and induces secondary swelling in a proportion of retinal ganglion cell (RGC) axons,accompanied by subsequent RGC degeneration (Sarkies et al., 2004). A previous study has shown that systemic neutralization of VEGF in mice resulted in substantial neural retinal cell death (Saint-Geniez et al., 2008). VEGF is known to play a crucial role in the pathogenesis of diabetic macular edema by promoting blood-retinal barrier (BRB) disruption and exacerbated vascular leakage (Zhang et al., 2008). Recent studies have demonstrated the neuroprotective effect of Ganoderma lucidum to reduce oxidative stress in vitro (Zhao et al., 2005), to induce neuronal differentiation (Cheung et al., 2000), and to prevent the harmful effects of the exterminating toxin Ab in Alzheimer’s disease in cultured rat neurons (Lai et al., 2008). Oral administration of Ganoderma lucidum has been shown to significantly reduce both cerebral infarct area and neuronal apoptosis in the ischemic cortex (Zhou et al.). lucidum, and have been used to strengthen body resistance, enhance and improve function of the nervous system, regulate immune system, stimulate anti-tumor activity, and eliminate fatigue (Zhou et al., 2012). lucidum spores (GLS) have high concentration of G. The fungi Ganoderma lucidum, a traditional Chinese medicine is recorded in Chinese materia medica treatise Shen Nong Materia Medica. PALABRAS CLAVE: Trauma de cabeza Retina Ganoderma lucidum Rata. Se investigó el efecto antioxidante de Ganoderma lucidum sobre la degeneración celular en la matriz extracelular y la barrera retiniana en la retina después del traumatismo craneal.

La inducción del trauma y los efectos protectores de Ganoderma lucidum en la retina fueron evaluados mediante análisis histológicos, inmunohistoquímicos y bioquímicos. Todas las ratas fueron decapitadas 5 días después. Ganoderma lucidum se administró durante 7 días después del trauma. Treinta ratas se dividieron en tres grupos: grupo 1, de control grupo 2, trauma grupo 3, de trauma + Gonoderma lucidum (20 ml / kg día, a través de una sonda gástrica). Ratas Sprague-Dawley fueron sometidas a una lesión cerebral traumática con un dispositivo de caída de peso usando un impacto de 300 g-1 m de peso-altura.

En esta investigación se evaluó el efecto protector de Gonaderin lucidum sobre el daño a la retina de ratas. Se estudiaron los diversos efectos bioquímicos, histológicos e inmunohistoquímicos en la retina producidos por una lesión y trauma a la cabeza.

RESUMEN: El traumatismo craneal afecta al nervio óptico en relación a su función y la agudeza visual. KEY WORDS: Head trauma Retina Ganoderma lucidum Rat. The antioxidant effect of Ganoderma lucidum on the cellular degeneration extracellular matrix and retinal barrier in retina after head trauma was investigated. Thirty rats were divided into three groups as group 1 control, 2 group trauma, 3 group trauma+Gonoderma lucidum (20 mL/kg per day via gastric gavage) Ganoderma lucidum was administered for 7 days after trauma.All rats were decapitated 5 days after the induction of trauma, and the protective effects of Ganoderma lucidum in retina were evaluated by histological, immunohistochemical and biochemical analyses. Sprague≭awley rats were subjected to traumatic brain injury with a weight-drop device using 300 g-1 m weightheight impact. The protective effect of Ganoderma lucidum was evaluated on the damage to the retina of the rats. As a result of head trauma occurring in the retina of the various biochemical, histological and immunohistochemical effects were investigated. SUMMARY: Head trauma affects the optic nerve visual function and visual acuity.

Protective Effects of Ganoderma lucidum on the Changes Made in the Retinal Damage Induced by Traumatic Head InjuryĮfectos Protectores de Ganoderma lucidum sobre los Cambios Producidos en el Daño Retinal Inducido por Lesión Traumática en la Cabezaġ Departments of Neurosurgery, Dicle University School of Medicine, Diyarbakir, Turkey.Ģ Department of Histology and Embryology, Dicle University School of Medicine, Diyarbakir, Turkey.

Desprendimiento de retina por traumatismo